ÖZET

Amaç

Sphingomonas paucimobilis is an opportunistic microorganism. Despite its low virulence leading to low mortality and morbidity, it causes serious infections, particularly in immunocompromised patients, In this study, it was aimed to evaluate the clinical characteristics, risk factors, laboratory findings, antibiotic susceptibilities of the causative agent, and patient outcomes of 20 pediatric patients followed due to bloodstream infections caused by S. paucimobilis

Gereç ve Yöntem

In this retrospective study conducted in a single-center tertiary hospital, pediatric patients who were followed up as inpatients, between 09.05.2016 and 22.05.2023, who grew S. paucimobilis in at least one blood culture and had symptoms and signs of bacteremia were evaluated. Demographic characteristics, underlying diseases, predisposing factors, antibiotic susceptibility test results, treatments and outcomes were reviewed.

Bulgular

Mean age was 74.7 (± 67.913) months, with 55% of patients being male. Healthcare-associated infections accounted for 70% of the cases. Carbapenems, amikacin, ceftriaxone, quinolones, and beta-lactam/ beta-lactamase inhibitors showed the least resistance among the antibiotics tested. No mortality attributable to S. paucimobilis was observed.

Sonuç

S. paucimobilis infections, both community-acquired and healthcare-associated, are increasingly recognized with relatively low mortality but potential to cause life-threatening infections. Healthcare providers should remain vigilant about its pathogenic potential, especially in immunocompromised patients. In this study, it was observed that bloodstream infections due to S. paucimobilis can lead to community-acquired or healthcare-associated infections and can be severe in people with immunosuppression and chronic diseases.

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ANAHTAR KELİMELER

Sphingomonas paucimobilis, child, opurtunistic, bloodstream infection

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GİRİŞ

Sphingomonas spp. are bacteria commonly found in nature, soil, and water. These bacteria are commonly found in water sources such as bathtubs, pipes, seawater, ice, river water, and mineral water; they have also been isolated in hospital environments in hemodialysis fluid, dental irrigation systems, distilled water, nebulizers, and hospital water systems. There are more than 30 species, and only paucimobilis is pathogenic. It is a non-fermentative, gramnegative, opportunistic bacillus (1). Its virulence is low. It causes both community-acquired and healthcare-associated infections (2). Healthcare-associated infections associated with S. paucimobilis have increased in recent years due to the widespread use of invasive medical devices and the increasing number of immunocompromised patients (3). It is known to cause bacteremia, pneumonia, catheter-related infections, meningitis, peritonitis, osteomyelitis, septic arthritis, postoperative endophthalmitis, empyema, spleen abscess, urinary tract infection, and biliary tract infection (4). They are resistant to penicillins and first-generation cephalosporins due to the production of chromosomally encoded beta-lactamases (5). Pediatric publications related to S. paucimobilis bacteremia are limited. It is a very rare cause of bacteremia. In our study, we aimed to evaluate the risk factors, antimicrobial susceptibility, treatment regimens, and clinical outcomes of S. paucimobilis and contribute to the literature

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GEREÇ VE YÖNTEM

Sphingomonas spp. are bacteria commonly found in nature, soil, and water. These bacteria are commonly found in water sources such as bathtubs, pipes, seawater, ice, river water, and mineral water; they have also been isolated in hospital environments in hemodialysis fluid, dental irrigation systems, distilled water, nebulizers, and hospital water systems. There are more than 30 species, and only paucimobilis is pathogenic. It is a non-fermentative, gramnegative, opportunistic bacillus (1). Its virulence is low. It causes both community-acquired and healthcare-associated infections (2). Healthcare-associated infections associated with S. paucimobilis have increased in recent years due to the widespread use of invasive medical devices and the increasing number of immunocompromised patients (3). It is known to cause bacteremia, pneumonia, catheter-related infections, meningitis, peritonitis, osteomyelitis, septic arthritis, postoperative endophthalmitis, empyema, spleen abscess, urinary tract infection, and biliary tract infection (4). They are resistant to penicillins and first-generation cephalosporins due to the production of chromosomally encoded beta-lactamases (5). Pediatric publications related to S. paucimobilis bacteremia are limited. It is a very rare cause of bacteremia. In our study, we aimed to evaluate the risk factors, antimicrobial susceptibility, treatment regimens, and clinical outcomes of S. paucimobilis and contribute to the literature

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BULGULAR

Sphingomonas spp. are bacteria commonly found in nature, soil, and water. These bacteria are commonly found in water sources such as bathtubs, pipes, seawater, ice, river water, and mineral water; they have also been isolated in hospital environments in hemodialysis fluid, dental irrigation systems, distilled water, nebulizers, and hospital water systems. There are more than 30 species, and only paucimobilis is pathogenic. It is a non-fermentative, gramnegative, opportunistic bacillus (1). Its virulence is low. It causes both community-acquired and healthcare-associated infections (2). Healthcare-associated infections associated with S. paucimobilis have increased in recent years due to the widespread use of invasive medical devices and the increasing number of immunocompromised patients (3). It is known to cause bacteremia, pneumonia, catheter-related infections, meningitis, peritonitis, osteomyelitis, septic arthritis, postoperative endophthalmitis, empyema, spleen abscess, urinary tract infection, and biliary tract infection (4). They are resistant to penicillins and first-generation cephalosporins due to the production of chromosomally encoded beta-lactamases (5). Pediatric publications related to S. paucimobilis bacteremia are limited. It is a very rare cause of bacteremia. In our study, we aimed to evaluate the risk factors, antimicrobial susceptibility, treatment regimens, and clinical outcomes of S. paucimobilis and contribute to the literature

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TARTIŞMA

Sphingomonas spp. are bacteria commonly found in nature, soil, and water. These bacteria are commonly found in water sources such as bathtubs, pipes, seawater, ice, river water, and mineral water; they have also been isolated in hospital environments in hemodialysis fluid, dental irrigation systems, distilled water, nebulizers, and hospital water systems. There are more than 30 species, and only paucimobilis is pathogenic. It is a non-fermentative, gramnegative, opportunistic bacillus (1). Its virulence is low. It causes both community-acquired and healthcare-associated infections (2). Healthcare-associated infections associated with S. paucimobilis have increased in recent years due to the widespread use of invasive medical devices and the increasing number of immunocompromised patients (3). It is known to cause bacteremia, pneumonia, catheter-related infections, meningitis, peritonitis, osteomyelitis, septic arthritis, postoperative endophthalmitis, empyema, spleen abscess, urinary tract infection, and biliary tract infection (4). They are resistant to penicillins and first-generation cephalosporins due to the production of chromosomally encoded beta-lactamases (5). Pediatric publications related to S. paucimobilis bacteremia are limited. It is a very rare cause of bacteremia. In our study, we aimed to evaluate the risk factors, antimicrobial susceptibility, treatment regimens, and clinical outcomes of S. paucimobilis and contribute to the literature

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SONUÇ

Sphingomonas spp. are bacteria commonly found in nature, soil, and water. These bacteria are commonly found in water sources such as bathtubs, pipes, seawater, ice, river water, and mineral water; they have also been isolated in hospital environments in hemodialysis fluid, dental irrigation systems, distilled water, nebulizers, and hospital water systems. There are more than 30 species, and only paucimobilis is pathogenic. It is a non-fermentative, gramnegative, opportunistic bacillus (1). Its virulence is low. It causes both community-acquired and healthcare-associated infections (2). Healthcare-associated infections associated with S. paucimobilis have increased in recent years due to the widespread use of invasive medical devices and the increasing number of immunocompromised patients (3). It is known to cause bacteremia, pneumonia, catheter-related infections, meningitis, peritonitis, osteomyelitis, septic arthritis, postoperative endophthalmitis, empyema, spleen abscess, urinary tract infection, and biliary tract infection (4). They are resistant to penicillins and first-generation cephalosporins due to the production of chromosomally encoded beta-lactamases (5). Pediatric publications related to S. paucimobilis bacteremia are limited. It is a very rare cause of bacteremia. In our study, we aimed to evaluate the risk factors, antimicrobial susceptibility, treatment regimens, and clinical outcomes of S. paucimobilis and contribute to the literature

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KAYNAKLAR